BDBM50351394 CHEMBL1819084

SMILES: CCC(CC)Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1Cl

InChI Key: InChIKey=AJUSHXCANNUJMW-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50351394   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50351394 (CHEMBL1819084) Show SMILES CCC(CC)Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1Cl |(-1.48,5.16,;-2.83,4.41,;-2.86,2.87,;-1.54,2.08,;-.19,2.83,;-4.2,2.13,;-4.23,.59,;-5.59,-.15,;-5.61,-1.7,;-6.96,-2.44,;-4.29,-2.55,;-2.93,-1.74,;-1.48,-2.23,;-.56,-1,;.98,-1.01,;-1.45,.26,;-2.92,-.2,;-1.02,-3.7,;-2.07,-4.83,;-1.61,-6.3,;-.1,-6.63,;.36,-8.1,;-.69,-9.24,;.94,-5.49,;.48,-4.03,;1.52,-2.89,)| Show InChI InChI=1S/C20H25ClN4O/c1-6-14(7-2)23-18-10-12(3)22-20-19(13(4)24-25(18)20)16-9-8-15(26-5)11-17(16)21/h8-11,14,23H,6-7H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP productio...				Bioorg Med Chem 19: 5432-45 (2011) Article DOI: 10.1016/j.bmc.2011.07.055 BindingDB Entry DOI: 10.7270/Q2Z038JX
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50351394 (CHEMBL1819084) Show SMILES CCC(CC)Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1Cl |(-1.48,5.16,;-2.83,4.41,;-2.86,2.87,;-1.54,2.08,;-.19,2.83,;-4.2,2.13,;-4.23,.59,;-5.59,-.15,;-5.61,-1.7,;-6.96,-2.44,;-4.29,-2.55,;-2.93,-1.74,;-1.48,-2.23,;-.56,-1,;.98,-1.01,;-1.45,.26,;-2.92,-.2,;-1.02,-3.7,;-2.07,-4.83,;-1.61,-6.3,;-.1,-6.63,;.36,-8.1,;-.69,-9.24,;.94,-5.49,;.48,-4.03,;1.52,-2.89,)| Show InChI InChI=1S/C20H25ClN4O/c1-6-14(7-2)23-18-10-12(3)22-20-19(13(4)24-25(18)20)16-9-8-15(26-5)11-17(16)21/h8-11,14,23H,6-7H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting				Bioorg Med Chem 19: 5432-45 (2011) Article DOI: 10.1016/j.bmc.2011.07.055 BindingDB Entry DOI: 10.7270/Q2Z038JX
					More data for this Ligand-Target Pair