BDBM50352580 CHEMBL1825159::US8772288, 47

SMILES: Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCOCC2)c1)C(=O)NC1CC1

InChI Key: InChIKey=PMWBLCWHEYJAND-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50352580   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50352580 (CHEMBL1825159 | US8772288, 47) Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCOCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O3/c1-13-2-3-14(20(26)24-16-4-5-16)10-17(13)15-11-18-19(23-12-15)22(21(27)25-18)6-8-28-9-7-22/h2-3,10-12,16H,4-9H2,1H3,(H,24,26)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	25
Almirall, S.A. US Patent					Assay Description Enzymatic activity assay was performed in 96-well microtiter plates (Corning, catalog number #3686) using a total volume of 50 ul of an assay buffer ...				US Patent US8772288 (2014) BindingDB Entry DOI: 10.7270/Q2T152BM
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50352580 (CHEMBL1825159 | US8772288, 47) Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCOCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O3/c1-13-2-3-14(20(26)24-16-4-5-16)10-17(13)15-11-18-19(23-12-15)22(21(27)25-18)6-8-28-9-7-22/h2-3,10-12,16H,4-9H2,1H3,(H,24,26)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA				Bioorg Med Chem Lett 21: 5270-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.033 BindingDB Entry DOI: 10.7270/Q2KD1Z8K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50352580 (CHEMBL1825159 | US8772288, 47) Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C22CCOCC2)c1)C(=O)NC1CC1 Show InChI InChI=1S/C22H23N3O3/c1-13-2-3-14(20(26)24-16-4-5-16)10-17(13)15-11-18-19(23-12-15)22(21(27)25-18)6-8-28-9-7-22/h2-3,10-12,16H,4-9H2,1H3,(H,24,26)(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay				Bioorg Med Chem Lett 21: 5270-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.033 BindingDB Entry DOI: 10.7270/Q2KD1Z8K
					More data for this Ligand-Target Pair