BDBM50352581 CHEMBL1825161::US8772288, 45

SMILES: Cc1ccc(cc1-c1cnc2c(NC(=O)C2(C)C)c1)C(=O)NC1CC1

InChI Key: InChIKey=JSZCUWBTIHIMPQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50352581   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50352581 (CHEMBL1825161 | US8772288, 45) Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C2(C)C)c1)C(=O)NC1CC1 Show InChI InChI=1S/C20H21N3O2/c1-11-4-5-12(18(24)22-14-6-7-14)8-15(11)13-9-16-17(21-10-13)20(2,3)19(25)23-16/h4-5,8-10,14H,6-7H2,1-3H3,(H,22,24)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	62	n/a	n/a	n/a	n/a	7.5	25
Almirall, S.A. US Patent					Assay Description Enzymatic activity assay was performed in 96-well microtiter plates (Corning, catalog number #3686) using a total volume of 50 ul of an assay buffer ...				US Patent US8772288 (2014) BindingDB Entry DOI: 10.7270/Q2T152BM
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50352581 (CHEMBL1825161 | US8772288, 45) Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C2(C)C)c1)C(=O)NC1CC1 Show InChI InChI=1S/C20H21N3O2/c1-11-4-5-12(18(24)22-14-6-7-14)8-15(11)13-9-16-17(21-10-13)20(2,3)19(25)23-16/h4-5,8-10,14H,6-7H2,1-3H3,(H,22,24)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	544	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA				Bioorg Med Chem Lett 21: 5270-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.033 BindingDB Entry DOI: 10.7270/Q2KD1Z8K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50352581 (CHEMBL1825161 | US8772288, 45) Show SMILES Cc1ccc(cc1-c1cnc2c(NC(=O)C2(C)C)c1)C(=O)NC1CC1 Show InChI InChI=1S/C20H21N3O2/c1-11-4-5-12(18(24)22-14-6-7-14)8-15(11)13-9-16-17(21-10-13)20(2,3)19(25)23-16/h4-5,8-10,14H,6-7H2,1-3H3,(H,22,24)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay				Bioorg Med Chem Lett 21: 5270-3 (2011) Article DOI: 10.1016/j.bmcl.2011.07.033 BindingDB Entry DOI: 10.7270/Q2KD1Z8K
					More data for this Ligand-Target Pair