BDBM50352824 CHEMBL1823630

SMILES: N[C@H](CNc1nnc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=ULPHTBRVXJBSIQ-HNNXBMFYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50352824   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50352824 (CHEMBL1823630) Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)14-4-1-11(2-5-14)7-15(24)10-25-19-28-27-18(30-19)12-3-6-16-13(8-12)9-17(29)26-16/h1-6,8,15H,7,9-10,24H2,(H,25,28)(H,26,29)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352824 (CHEMBL1823630) Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)14-4-1-11(2-5-14)7-15(24)10-25-19-28-27-18(30-19)12-3-6-16-13(8-12)9-17(29)26-16/h1-6,8,15H,7,9-10,24H2,(H,25,28)(H,26,29)/t15-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50352824 (CHEMBL1823630) Show SMILES N[C@H](CNc1nnc(s1)-c1ccc2NC(=O)Cc2c1)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H18F3N5OS/c21-20(22,23)14-4-1-11(2-5-14)7-15(24)10-25-19-28-27-18(30-19)12-3-6-16-13(8-12)9-17(29)26-16/h1-6,8,15H,7,9-10,24H2,(H,25,28)(H,26,29)/t15-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT1-mediated PRAS40 phosphorylation in human U87MG cells after 1 hr in presence of 5% FBS by ELISA assay				Bioorg Med Chem Lett 21: 5191-6 (2011) Article DOI: 10.1016/j.bmcl.2011.07.056 BindingDB Entry DOI: 10.7270/Q21G0MNQ
					More data for this Ligand-Target Pair