BDBM50353038 CHEMBL4175290

SMILES: [H][C@@]12CC[C@H](c3ccc4c(N)n[nH]c4c3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C

InChI Key: InChIKey=XIWWBWKHTFXTLG-VFVKCCKNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50353038   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50353038 (CHEMBL4175290) Show SMILES [H][C@@]12CC[C@H](c3ccc4c(N)n[nH]c4c3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C |r,t:28| Show InChI InChI=1S/C26H35N3O/c1-25-11-9-17(30)14-16(25)4-6-18-21-8-7-20(26(21,2)12-10-22(18)25)15-3-5-19-23(13-15)28-29-24(19)27/h3-5,13,17-18,20-22,30H,6-12,14H2,1-2H3,(H3,27,28,29)/t17-,18-,20+,21-,22-,25-,26+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	682	n/a	n/a	n/a	n/a	n/a	n/a
Dana-Farber Cancer Institute Curated by ChEMBL					Assay Description Inhibition of CDK8 (unknown origin)				ACS Med Chem Lett 9: 540-545 (2018) Article DOI: 10.1021/acsmedchemlett.8b00011 BindingDB Entry DOI: 10.7270/Q2125W6Z
					More data for this Ligand-Target Pair