BDBM50354038 CHEMBL1830527

SMILES: CCC(CC)n1ccc2c(Nc3c(C)cc(C)cc3C)nc3ccnn3c12

InChI Key: InChIKey=GAFQBRBERHUGTG-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50354038   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50354038 (CHEMBL1830527) Show SMILES CCC(CC)n1ccc2c(Nc3c(C)cc(C)cc3C)nc3ccnn3c12 Show InChI InChI=1S/C22H27N5/c1-6-17(7-2)26-11-9-18-21(24-19-8-10-23-27(19)22(18)26)25-20-15(4)12-14(3)13-16(20)5/h8-13,17H,6-7H2,1-5H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting				Bioorg Med Chem 19: 5955-66 (2011) Article DOI: 10.1016/j.bmc.2011.08.055 BindingDB Entry DOI: 10.7270/Q24X5862
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50354038 (CHEMBL1830527) Show SMILES CCC(CC)n1ccc2c(Nc3c(C)cc(C)cc3C)nc3ccnn3c12 Show InChI InChI=1S/C22H27N5/c1-6-17(7-2)26-11-9-18-21(24-19-8-10-23-27(19)22(18)26)25-20-15(4)12-14(3)13-16(20)5/h8-13,17H,6-7H2,1-5H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.10	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...				Bioorg Med Chem 19: 5955-66 (2011) Article DOI: 10.1016/j.bmc.2011.08.055 BindingDB Entry DOI: 10.7270/Q24X5862
					More data for this Ligand-Target Pair