BDBM50354741 CHEMBL1834081

SMILES: FC(F)(F)c1cnc(N2CCN(CC2)S(=O)(=O)c2ccc3ccccc3c2)c(Cl)c1

InChI Key: InChIKey=SBLKQUPOVXEMDD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50354741   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50354741 (CHEMBL1834081) Show SMILES FC(F)(F)c1cnc(N2CCN(CC2)S(=O)(=O)c2ccc3ccccc3c2)c(Cl)c1 Show InChI InChI=1S/C20H17ClF3N3O2S/c21-18-12-16(20(22,23)24)13-25-19(18)26-7-9-27(10-8-26)30(28,29)17-6-5-14-3-1-2-4-15(14)11-17/h1-6,11-13H,7-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	32.7	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Pharmaceutical Holding Co. Ltd Curated by ChEMBL					Assay Description Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...				Bioorg Med Chem Lett 21: 5739-44 (2011) Article DOI: 10.1016/j.bmcl.2011.08.019 BindingDB Entry DOI: 10.7270/Q27H1K0C
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