BDBM50355733 CHEMBL1911283

SMILES: CN(C)C(=O)c1ccc(cc1)-c1ccc2C(c3ccccc3Oc2c1)C(C)(C)C(=O)Nc1nncs1

InChI Key: InChIKey=ORVRISQWQZXOFB-UHFFFAOYSA-N

Data: 1 KI  5 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50355733   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355733 (CHEMBL1911283) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(c3ccccc3Oc2c1)C(C)(C)C(=O)Nc1nncs1 Show InChI InChI=1S/C28H26N4O3S/c1-28(2,26(34)30-27-31-29-16-36-27)24-20-7-5-6-8-22(20)35-23-15-19(13-14-21(23)24)17-9-11-18(12-10-17)25(33)32(3)4/h5-16,24H,1-4H3,(H,30,31,34)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	8.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assay				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355733 (CHEMBL1911283) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(c3ccccc3Oc2c1)C(C)(C)C(=O)Nc1nncs1 Show InChI InChI=1S/C28H26N4O3S/c1-28(2,26(34)30-27-31-29-16-36-27)24-20-7-5-6-8-22(20)35-23-15-19(13-14-21(23)24)17-9-11-18(12-10-17)25(33)32(3)4/h5-16,24H,1-4H3,(H,30,31,34)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	77.9	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor alpha in phorbol myristate acetate-stimulated human A549 cells assessed as inhibition of AP1 resp...				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355733 (CHEMBL1911283) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(c3ccccc3Oc2c1)C(C)(C)C(=O)Nc1nncs1 Show InChI InChI=1S/C28H26N4O3S/c1-28(2,26(34)30-27-31-29-16-36-27)24-20-7-5-6-8-22(20)35-23-15-19(13-14-21(23)24)17-9-11-18(12-10-17)25(33)32(3)4/h5-16,24H,1-4H3,(H,30,31,34)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transactivation activity at glucocorticoid receptor alpha human 13D3/Huh7 cells assessed as induction of TAT activity after 4 hrs by spectrophotometr...				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355733 (CHEMBL1911283) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(c3ccccc3Oc2c1)C(C)(C)C(=O)Nc1nncs1 Show InChI InChI=1S/C28H26N4O3S/c1-28(2,26(34)30-27-31-29-16-36-27)24-20-7-5-6-8-22(20)35-23-15-19(13-14-21(23)24)17-9-11-18(12-10-17)25(33)32(3)4/h5-16,24H,1-4H3,(H,30,31,34)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	610	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transactivation activity at GR-alpha in human NP1 Hela cells assessed as inhibition of GAL4-DBD after 20 hrs by luciferase reporter gene assay				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355733 (CHEMBL1911283) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(c3ccccc3Oc2c1)C(C)(C)C(=O)Nc1nncs1 Show InChI InChI=1S/C28H26N4O3S/c1-28(2,26(34)30-27-31-29-16-36-27)24-20-7-5-6-8-22(20)35-23-15-19(13-14-21(23)24)17-9-11-18(12-10-17)25(33)32(3)4/h5-16,24H,1-4H3,(H,30,31,34)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transactivation activity at GR-alpha in human NP1 Hela cells assessed as induction of GAL4-DBD after 20 hrs by luciferase reporter gene assay				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355733 (CHEMBL1911283) Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(c3ccccc3Oc2c1)C(C)(C)C(=O)Nc1nncs1 Show InChI InChI=1S/C28H26N4O3S/c1-28(2,26(34)30-27-31-29-16-36-27)24-20-7-5-6-8-22(20)35-23-15-19(13-14-21(23)24)17-9-11-18(12-10-17)25(33)32(3)4/h5-16,24H,1-4H3,(H,30,31,34)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	74.9	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor alpha in IL-1beta-stimulated human A549 cells assessed as inhibition of NFkappaB-dependent E-sele...				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair