Found 3 hits for monomerid = 50360052 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360052
(CHEMBL1928549)Show SMILES CCCC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:4.4| Show InChI InChI=1S/C19H18N6O4S/c1-3-4-17(16-12-21-24-8-7-14(11-20)9-18(16)24)22-23-30(28,29)19-10-15(25(26)27)6-5-13(19)2/h5-10,12,23H,3-4H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360052
(CHEMBL1928549)Show SMILES CCCC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:4.4| Show InChI InChI=1S/C19H18N6O4S/c1-3-4-17(16-12-21-24-8-7-14(11-20)9-18(16)24)22-23-30(28,29)19-10-15(25(26)27)6-5-13(19)2/h5-10,12,23H,3-4H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360052
(CHEMBL1928549)Show SMILES CCCC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:4.4| Show InChI InChI=1S/C19H18N6O4S/c1-3-4-17(16-12-21-24-8-7-14(11-20)9-18(16)24)22-23-30(28,29)19-10-15(25(26)27)6-5-13(19)2/h5-10,12,23H,3-4H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |