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BDBM50365375 CHEMBL4162798

SMILES: Cn1cnc(c1)S(=O)(=O)N1CC(Nc2cccc(c2)C(F)(F)F)C(C1)c1ccccc1

InChI Key: InChIKey=KPMMXLGUHRNCOE-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50365375   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))		BDBM50365375
PNG
(CHEMBL4162798)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1CC(Nc2cccc(c2)C(F)(F)F)C(C1)c1ccccc1
Show InChI InChI=1S/C21H21F3N4O2S/c1-27-13-20(25-14-27)31(29,30)28-11-18(15-6-3-2-4-7-15)19(12-28)26-17-9-5-8-16(10-17)21(22,23)24/h2-10,13-14,18-19,26H,11-12H2,1H3
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 0.00800n/an/an/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...

J Med Chem 61: 7486-7502 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00295
BindingDB Entry DOI: 10.7270/Q2CC137K
More data for this
Ligand-Target Pair