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SMILES: Cn1cc(NC(=O)c2c(Cl)cccc2Cl)c(n1)C(=O)NC1CCN(CC1)C(=O)c1c(Cl)cccc1Cl

InChI Key: InChIKey=WWSSAJMOUMFEBT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50368875   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM50368875
PNG
(CHEMBL4165150)
Show SMILES Cn1cc(NC(=O)c2c(Cl)cccc2Cl)c(n1)C(=O)NC1CCN(CC1)C(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H21Cl4N5O3/c1-32-12-18(30-22(34)19-14(25)4-2-5-15(19)26)21(31-32)23(35)29-13-8-10-33(11-9-13)24(36)20-16(27)6-3-7-17(20)28/h2-7,12-13H,8-11H2,1H3,(H,29,35)(H,30,34)
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His6-tagged human full length CDK2/N-terminal GST-tagged human full length Cyclin A using histone H1 and [gamma-32P]-ATP inc...

J Med Chem 61: 7700-7709 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00669
BindingDB Entry DOI: 10.7270/Q2GX4F3H
More data for this
Ligand-Target Pair