null

SMILES: [H][C@@]12CC[C@@](O)(C#CC(C)(C)C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(N(C)C)c(OC)c1

InChI Key: InChIKey=FPEFUKDBZOEPMQ-XIAJYCBGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50368942   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50368942 (CHEMBL4169408 | US11124537, TABLE 3.15.1) Show SMILES [H][C@@]12CC[C@@](O)(C#CC(C)(C)C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(N(C)C)c(OC)c1 |r,c:17,23| Show InChI InChI=1S/C33H43NO3/c1-31(2,3)16-17-33(36)15-14-27-25-11-8-21-18-23(35)10-12-24(21)30(25)26(20-32(27,33)4)22-9-13-28(34(5)6)29(19-22)37-7/h9,13,18-19,25-27,36H,8,10-12,14-15,20H2,1-7H3/t25-,26+,27-,32-,33+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a
ORIC Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human GR expressed in CHO-K1 cells incubated for 20 hrs by luciferase reporter gene assay				J Med Chem 61: 7767-7784 (2018) Article DOI: 10.1021/acs.jmedchem.8b00743 BindingDB Entry DOI: 10.7270/Q2C53PDJ
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50368942 (CHEMBL4169408 | US11124537, TABLE 3.15.1) Show SMILES [H][C@@]12CC[C@@](O)(C#CC(C)(C)C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(N(C)C)c(OC)c1 |r,c:17,23| Show InChI InChI=1S/C33H43NO3/c1-31(2,3)16-17-33(36)15-14-27-25-11-8-21-18-23(35)10-12-24(21)30(25)26(20-32(27,33)4)22-9-13-28(34(5)6)29(19-22)37-7/h9,13,18-19,25-27,36H,8,10-12,14-15,20H2,1-7H3/t25-,26+,27-,32-,33+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50368942 (CHEMBL4169408 | US11124537, TABLE 3.15.1) Show SMILES [H][C@@]12CC[C@@](O)(C#CC(C)(C)C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(N(C)C)c(OC)c1 |r,c:17,23| Show InChI InChI=1S/C33H43NO3/c1-31(2,3)16-17-33(36)15-14-27-25-11-8-21-18-23(35)10-12-24(21)30(25)26(20-32(27,33)4)22-9-13-28(34(5)6)29(19-22)37-7/h9,13,18-19,25-27,36H,8,10-12,14-15,20H2,1-7H3/t25-,26+,27-,32-,33+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
ORIC Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...				J Med Chem 61: 7767-7784 (2018) Article DOI: 10.1021/acs.jmedchem.8b00743 BindingDB Entry DOI: 10.7270/Q2C53PDJ
					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM50368942 (CHEMBL4169408 | US11124537, TABLE 3.15.1) Show SMILES [H][C@@]12CC[C@@](O)(C#CC(C)(C)C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(N(C)C)c(OC)c1 |r,c:17,23| Show InChI InChI=1S/C33H43NO3/c1-31(2,3)16-17-33(36)15-14-27-25-11-8-21-18-23(35)10-12-24(21)30(25)26(20-32(27,33)4)22-9-13-28(34(5)6)29(19-22)37-7/h9,13,18-19,25-27,36H,8,10-12,14-15,20H2,1-7H3/t25-,26+,27-,32-,33+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a
ORIC Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at AR (unknown origin) expressed in human LNCaP cells incubated for 20 hrs by luciferase reporter gene assay				J Med Chem 61: 7767-7784 (2018) Article DOI: 10.1021/acs.jmedchem.8b00743 BindingDB Entry DOI: 10.7270/Q2C53PDJ
					More data for this Ligand-Target Pair