BDBM50369677 CHEMBL4172824

SMILES: Cc1cc(Nc2ncc(o2)-c2ccc(F)cc2)cc(C)c1O

InChI Key: InChIKey=NWGBKDIIVCLWCJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50369677   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50369677 (CHEMBL4172824) Show SMILES Cc1cc(Nc2ncc(o2)-c2ccc(F)cc2)cc(C)c1O Show InChI InChI=1S/C17H15FN2O2/c1-10-7-14(8-11(2)16(10)21)20-17-19-9-15(22-17)12-3-5-13(18)6-4-12/h3-9,21H,1-2H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
School of Advanced Sciences Curated by ChEMBL					Assay Description Inhibition of 5-LOX (unknown origin) after 5 mins by colorimetric method				Bioorg Med Chem 27: 3745-3759 (2019) Article DOI: 10.1016/j.bmc.2019.06.040
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50369677 (CHEMBL4172824) Show SMILES Cc1cc(Nc2ncc(o2)-c2ccc(F)cc2)cc(C)c1O Show InChI InChI=1S/C17H15FN2O2/c1-10-7-14(8-11(2)16(10)21)20-17-19-9-15(22-17)12-3-5-13(18)6-4-12/h3-9,21H,1-2H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
University of Campania "Luigi Vanvitelli" Curated by ChEMBL					Assay Description Inhibition of 5-LOX (unknown origin)				Eur J Med Chem 153: 65-72 (2018) Article DOI: 10.1016/j.ejmech.2017.10.020 BindingDB Entry DOI: 10.7270/Q26H4M0M
					More data for this Ligand-Target Pair