BindingDB PrimarySearch

BDBM50370181 CHEMBL4159382

SMILES: Cc1cc(\N=N\c2ccc(cc2)S(=O)(=O)NC2CCCC2)c(N)cc1O

InChI Key: InChIKey=IRKMSULWLDLTIK-QZQOTICOSA-N

Data: 13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50370181
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG54 RNA expression preincubated for 24 hrs followed ...				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(BD2) (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced grobeta RNA expression preincubated for 24 hrs followe...				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD4 BD1 (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD2 BD2 (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain testis-specific protein (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRDT BD1 (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 3 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD3 BD1 (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG56 RNA expression preincubated for 24 hrs followed ...				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced IL-8 RNA expression preincubated for 24 hrs followed b...				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD4 BD2 (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 3 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD3 BD2 (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain testis-specific protein (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRDT BD2 (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of CBP (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 1 domain(BRD2 BD1) (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	772	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2) (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	1.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 3 Bromo 1 domain(BRD3 BD1) (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	2.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 3 Bromo 2 domain(BRD3 BD2) (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)(BD1) (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	3.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Bromodomain testis-specific protein (BRDT)(BD2) (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	3.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4)(BD1) (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars		n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 (Homo sapiens (Human))	BDBM50370181 (CHEMBL4159382 \| US11117865, Compound ZL0454) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	772	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Medical Branch Curated by ChEMBL					Assay Description Inhibition of BRD2 BD1 (unknown origin) after 1 hr by TR-FRET assay				Eur J Med Chem 151: 450-461 (2018) Article DOI: 10.1016/j.ejmech.2018.04.006 BindingDB Entry DOI: 10.7270/Q2X069KM
University of Texas Medical Branch Curated by ChEMBL					More data for this Ligand-Target Pair