BDBM50372518 CHEMBL257234
SMILES: O=S(=O)(Nc1cccc2cccnc12)c1cccs1
InChI Key: InChIKey=CPSRVVXBTZFZPM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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NF-kappa-B inhibitor alpha (Homo sapiens (Human)) | BDBM50372518![]() (CHEMBL257234) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a |
Columbia University Curated by ChEMBL | Assay Description Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assay | Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50372518![]() (CHEMBL257234) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition recombinant human N-terminal 6His-tagged GLO1 (2 to 184 residues) expressed in Escherichia coli using MG as substrate preincubated for 15 ... | J Med Chem 62: 1609-1625 (2019) Article DOI: 10.1021/acs.jmedchem.8b01868 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NF-kappa-B inhibitor alpha (Homo sapiens (Human)) | BDBM50372518![]() (CHEMBL257234) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
Columbia University Curated by ChEMBL | Assay Description Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to r... | Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor p65 (Homo sapiens (Human)) | BDBM50372518![]() (CHEMBL257234) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University Curated by ChEMBL | Assay Description Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC | Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63 | |||||||||||
More data for this Ligand-Target Pair |