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SMILES: CC(C)(C)c1nnc(NC(=O)Nc2ccc(Oc3ccncc3)cc2)s1

InChI Key: InChIKey=CSQHSUSXDWAPHD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50375253   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM50375253
PNG
(CHEMBL440588)
Show SMILES CC(C)(C)c1nnc(NC(=O)Nc2ccc(Oc3ccncc3)cc2)s1
Show InChI InChI=1S/C18H19N5O2S/c1-18(2,3)15-22-23-17(26-15)21-16(24)20-12-4-6-13(7-5-12)25-14-8-10-19-11-9-14/h4-11H,1-3H3,(H2,20,21,23,24)
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Article
PubMed
n/an/a 8.60E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Raf1 kinase

Bioorg Med Chem Lett 18: 2346-50 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.068
BindingDB Entry DOI: 10.7270/Q25X29S8
More data for this
Ligand-Target Pair