BDBM50375823 CHEMBL407847

SMILES: Cn1c(ccc1-c1cc2c(NC(=O)C22CCCC2)c(F)c1)C#N

InChI Key: InChIKey=BWIVIIVAVHAPAO-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50375823   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50375823 (CHEMBL407847) Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C22CCCC2)c(F)c1)C#N Show InChI InChI=1S/C18H16FN3O/c1-22-12(10-20)4-5-15(22)11-8-13-16(14(19)9-11)21-17(23)18(13)6-2-3-7-18/h4-5,8-9H,2-3,6-7H2,1H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at human PR expressed in human T47D cells assessed as stimulation of alkaline phosphatase				J Med Chem 51: 1861-73 (2008) Article DOI: 10.1021/jm701080t BindingDB Entry DOI: 10.7270/Q2G44R56
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50375823 (CHEMBL407847) Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C22CCCC2)c(F)c1)C#N Show InChI InChI=1S/C18H16FN3O/c1-22-12(10-20)4-5-15(22)11-8-13-16(14(19)9-11)21-17(23)18(13)6-2-3-7-18/h4-5,8-9H,2-3,6-7H2,1H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14.7	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay				J Med Chem 51: 1861-73 (2008) Article DOI: 10.1021/jm701080t BindingDB Entry DOI: 10.7270/Q2G44R56
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50375823 (CHEMBL407847) Show SMILES Cn1c(ccc1-c1cc2c(NC(=O)C22CCCC2)c(F)c1)C#N Show InChI InChI=1S/C18H16FN3O/c1-22-12(10-20)4-5-15(22)11-8-13-16(14(19)9-11)21-17(23)18(13)6-2-3-7-18/h4-5,8-9H,2-3,6-7H2,1H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase				J Med Chem 51: 1861-73 (2008) Article DOI: 10.1021/jm701080t BindingDB Entry DOI: 10.7270/Q2G44R56
					More data for this Ligand-Target Pair