BDBM50376249 CHEMBL265710

SMILES: CNC(=O)c1ccc(C)c(Nc2nc(nc3n(ncc23)-c2ccccc2)N2CCCN(C)CC2)c1

InChI Key: InChIKey=WJDAXCXTJSCIBR-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50376249   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50376249 (CHEMBL265710) Show SMILES CNC(=O)c1ccc(C)c(Nc2nc(nc3n(ncc23)-c2ccccc2)N2CCCN(C)CC2)c1 Show InChI InChI=1S/C26H30N8O/c1-18-10-11-19(25(35)27-2)16-22(18)29-23-21-17-28-34(20-8-5-4-6-9-20)24(21)31-26(30-23)33-13-7-12-32(3)14-15-33/h4-6,8-11,16-17H,7,12-15H2,1-3H3,(H,27,35)(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant p38alpha-mediated myelin basic protein phosphorylation				Bioorg Med Chem Lett 18: 2652-7 (2008) Article DOI: 10.1016/j.bmcl.2008.03.019 BindingDB Entry DOI: 10.7270/Q2C53MR6
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