BDBM50376250 CHEMBL260807

SMILES: CNC(=O)c1ccc(C)c(Nc2nc(nc3n(ncc23)-c2ccccc2)N(C)CCC#N)c1

InChI Key: InChIKey=OUOPQKOQBYYHRP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50376250   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50376250 (CHEMBL260807) Show SMILES CNC(=O)c1ccc(C)c(Nc2nc(nc3n(ncc23)-c2ccccc2)N(C)CCC#N)c1 Show InChI InChI=1S/C24H24N8O/c1-16-10-11-17(23(33)26-2)14-20(16)28-21-19-15-27-32(18-8-5-4-6-9-18)22(19)30-24(29-21)31(3)13-7-12-25/h4-6,8-11,14-15H,7,13H2,1-3H3,(H,26,33)(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant p38alpha-mediated myelin basic protein phosphorylation				Bioorg Med Chem Lett 18: 2652-7 (2008) Article DOI: 10.1016/j.bmcl.2008.03.019 BindingDB Entry DOI: 10.7270/Q2C53MR6
					More data for this Ligand-Target Pair