null

SMILES: NC(=O)c1cccc(Nc2nccc(n2)-c2nc([nH]c2-c2cccc(NS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)c2)C2CC2)c1

InChI Key: InChIKey=OCBCSZRKQIGAFJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50377768   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50377768 (CHEMBL402424) Show SMILES NC(=O)c1cccc(Nc2nccc(n2)-c2nc([nH]c2-c2cccc(NS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)c2)C2CC2)c1 Show InChI InChI=1S/C30H25Cl2N7O3S/c31-23-10-7-17(13-24(23)32)16-43(41,42)39-22-6-1-3-19(14-22)26-27(38-29(37-26)18-8-9-18)25-11-12-34-30(36-25)35-21-5-2-4-20(15-21)28(33)40/h1-7,10-15,18,39H,8-9,16H2,(H2,33,40)(H,37,38)(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	887	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of B-RAF kinase				Bioorg Med Chem Lett 18: 2825-9 (2008) Article DOI: 10.1016/j.bmcl.2008.04.002 BindingDB Entry DOI: 10.7270/Q2DJ5GH8
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50377768 (CHEMBL402424) Show SMILES NC(=O)c1cccc(Nc2nccc(n2)-c2nc([nH]c2-c2cccc(NS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)c2)C2CC2)c1 Show InChI InChI=1S/C30H25Cl2N7O3S/c31-23-10-7-17(13-24(23)32)16-43(41,42)39-22-6-1-3-19(14-22)26-27(38-29(37-26)18-8-9-18)25-11-12-34-30(36-25)35-21-5-2-4-20(15-21)28(33)40/h1-7,10-15,18,39H,8-9,16H2,(H2,33,40)(H,37,38)(H,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Inhibition of C-RAF kinase				Bioorg Med Chem Lett 18: 2825-9 (2008) Article DOI: 10.1016/j.bmcl.2008.04.002 BindingDB Entry DOI: 10.7270/Q2DJ5GH8
					More data for this Ligand-Target Pair