null
SMILES: CCCCOc1c(ccc2c(N)ncnc12)-n1cc(C)c2c1CC(C)(C)CC2=O
InChI Key: InChIKey=BUUQUJYPNFCHTQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM50379846![]() (CHEMBL2011848) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Serenex Inc. Curated by ChEMBL | Assay Description Inhibition of HSP90-mediated Her2 degradation in human SKBR3 cells after 24 hrs by ELISA | Bioorg Med Chem Lett 22: 2550-4 (2012) Article DOI: 10.1016/j.bmcl.2012.01.137 BindingDB Entry DOI: 10.7270/Q2WQ04TB | |||||||||||
More data for this Ligand-Target Pair |