null
SMILES: COc1ccccc1CNC(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F
InChI Key: InChIKey=AQRRJVYSRQOMOV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50379969 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50379969
(CHEMBL2012216)Show SMILES COc1ccccc1CNC(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C24H21F3N4O4/c1-33-16-6-4-3-5-13(16)12-29-22(32)21-18(11-28)35-23(31-21)15-7-9-17(34-2)20-14(15)8-10-19(30-20)24(25,26)27/h3-10H,11-12,28H2,1-2H3,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of PDE4B |
Bioorg Med Chem Lett 22: 2594-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.115 BindingDB Entry DOI: 10.7270/Q2CN74X0 |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50379969
(CHEMBL2012216)Show SMILES COc1ccccc1CNC(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F Show InChI InChI=1S/C24H21F3N4O4/c1-33-16-6-4-3-5-13(16)12-29-22(32)21-18(11-28)35-23(31-21)15-7-9-17(34-2)20-14(15)8-10-19(30-20)24(25,26)27/h3-10H,11-12,28H2,1-2H3,(H,29,32) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of PDE11 |
Bioorg Med Chem Lett 22: 2594-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.115 BindingDB Entry DOI: 10.7270/Q2CN74X0 |
More data for this Ligand-Target Pair | |