BDBM50379989 CHEMBL2012211

SMILES: COc1ccc(-c2nc(C(=O)NCc3ccc(cc3)S(C)(=O)=O)c(CN)o2)c2ccc(nc12)C(F)(F)F

InChI Key: InChIKey=HHBCFJBFFOKCIJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50379989   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50379989 (CHEMBL2012211) Show SMILES COc1ccc(-c2nc(C(=O)NCc3ccc(cc3)S(C)(=O)=O)c(CN)o2)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C24H21F3N4O5S/c1-35-17-9-7-16(15-8-10-19(24(25,26)27)30-20(15)17)23-31-21(18(11-28)36-23)22(32)29-12-13-3-5-14(6-4-13)37(2,33)34/h3-10H,11-12,28H2,1-2H3,(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of PDE4B				Bioorg Med Chem Lett 22: 2594-7 (2012) Article DOI: 10.1016/j.bmcl.2012.01.115 BindingDB Entry DOI: 10.7270/Q2CN74X0
					More data for this Ligand-Target Pair