BDBM50381368 CHEMBL2016784

SMILES: Cc1nc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(O)(CC1)c1ccc(F)cc1

InChI Key: InChIKey=JJCJCHICGRXGFD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50381368   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50381368 (CHEMBL2016784) Show SMILES Cc1nc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(O)(CC1)c1ccc(F)cc1 Show InChI InChI=1S/C29H26F4N4O4/c1-18-24-16-21(35-26(38)17-40-22-7-9-23(10-8-22)41-29(31,32)33)6-11-25(24)36-27(34-18)37-14-12-28(39,13-15-37)19-2-4-20(30)5-3-19/h2-11,16,39H,12-15,17H2,1H3,(H,35,38)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Dr. Reddy's Laboratories Ltd Curated by ChEMBL					Assay Description Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by SPA binding assay				Bioorg Med Chem Lett 22: 3157-62 (2012) Article DOI: 10.1016/j.bmcl.2012.03.050 BindingDB Entry DOI: 10.7270/Q2D79CFJ
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50381368 (CHEMBL2016784) Show SMILES Cc1nc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(O)(CC1)c1ccc(F)cc1 Show InChI InChI=1S/C29H26F4N4O4/c1-18-24-16-21(35-26(38)17-40-22-7-9-23(10-8-22)41-29(31,32)33)6-11-25(24)36-27(34-18)37-14-12-28(39,13-15-37)19-2-4-20(30)5-3-19/h2-11,16,39H,12-15,17H2,1H3,(H,35,38)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Dr. Reddy's Laboratories Ltd Curated by ChEMBL					Assay Description Antagonist activity at human MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH peptide mediated response measuring [3H]inositol phosphate...				Bioorg Med Chem Lett 22: 3157-62 (2012) Article DOI: 10.1016/j.bmcl.2012.03.050 BindingDB Entry DOI: 10.7270/Q2D79CFJ
					More data for this Ligand-Target Pair