BDBM50381514 CHEMBL2017745

SMILES: C\C(=C/C(=O)Nc1ccc2nc(nc(C)c2c1)N1CCC(CC1)N1CCCC1=O)c1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=PCGFEMQZPUYTBH-FBMGVBCBSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50381514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50381514 (CHEMBL2017745) Show SMILES C\C(=C/C(=O)Nc1ccc2nc(nc(C)c2c1)N1CCC(CC1)N1CCCC1=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C29H30F3N5O3/c1-18(20-5-8-23(9-6-20)40-29(30,31)32)16-26(38)34-21-7-10-25-24(17-21)19(2)33-28(35-25)36-14-11-22(12-15-36)37-13-3-4-27(37)39/h5-10,16-17,22H,3-4,11-15H2,1-2H3,(H,34,38)/b18-16+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Dr. Reddy's Laboratories Ltd Curated by ChEMBL					Assay Description Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated...				Bioorg Med Chem Lett 22: 3163-7 (2012) Article DOI: 10.1016/j.bmcl.2012.03.049 BindingDB Entry DOI: 10.7270/Q20Z7485
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50381514 (CHEMBL2017745) Show SMILES C\C(=C/C(=O)Nc1ccc2nc(nc(C)c2c1)N1CCC(CC1)N1CCCC1=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C29H30F3N5O3/c1-18(20-5-8-23(9-6-20)40-29(30,31)32)16-26(38)34-21-7-10-25-24(17-21)19(2)33-28(35-25)36-14-11-22(12-15-36)37-13-3-4-27(37)39/h5-10,16-17,22H,3-4,11-15H2,1-2H3,(H,34,38)/b18-16+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Dr. Reddy's Laboratories Ltd Curated by ChEMBL					Assay Description Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay				Bioorg Med Chem Lett 22: 3163-7 (2012) Article DOI: 10.1016/j.bmcl.2012.03.049 BindingDB Entry DOI: 10.7270/Q20Z7485
					More data for this Ligand-Target Pair