BDBM50382649 CHEMBL2024000

SMILES: COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(Oc3ccccc3)c2)cc(OC)c1OC

InChI Key: InChIKey=MTMPSUGSCASWJV-QHCPKHFHSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50382649   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50382649 (CHEMBL2024000) Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(Oc3ccccc3)c2)cc(OC)c1OC |r| Show InChI InChI=1S/C32H35N5O5/c1-39-27-18-24(19-28(40-2)30(27)41-3)35-32-33-15-14-29(36-32)37-16-8-10-23(21-37)31(38)34-20-22-9-7-13-26(17-22)42-25-11-5-4-6-12-25/h4-7,9,11-15,17-19,23H,8,10,16,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...				J Med Chem 55: 1698-705 (2012) Article DOI: 10.1021/jm201565s BindingDB Entry DOI: 10.7270/Q20P111R
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50382649 (CHEMBL2024000) Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(Oc3ccccc3)c2)cc(OC)c1OC |r| Show InChI InChI=1S/C32H35N5O5/c1-39-27-18-24(19-28(40-2)30(27)41-3)35-32-33-15-14-29(36-32)37-16-8-10-23(21-37)31(38)34-20-22-9-7-13-26(17-22)42-25-11-5-4-6-12-25/h4-7,9,11-15,17-19,23H,8,10,16,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	192	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...				J Med Chem 55: 1698-705 (2012) Article DOI: 10.1021/jm201565s BindingDB Entry DOI: 10.7270/Q20P111R
					More data for this Ligand-Target Pair