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SMILES: COc1cc(ccc1Nc1ncc2CN(C)C(=O)N(c3cccc(N)c3)c2n1)N1CCN(C)CC1

InChI Key: InChIKey=AAFHSECTTHOVFV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50383296   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50383296
PNG
(CHEMBL2029442)
Show SMILES COc1cc(ccc1Nc1ncc2CN(C)C(=O)N(c3cccc(N)c3)c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C25H30N8O2/c1-30-9-11-32(12-10-30)19-7-8-21(22(14-19)35-3)28-24-27-15-17-16-31(2)25(34)33(23(17)29-24)20-6-4-5-18(26)13-20/h4-8,13-15H,9-12,16,26H2,1-3H3,(H,27,28,29)
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KEGG

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1.5 hr by FRET assay

J Med Chem 55: 2711-23 (2012)


Article DOI: 10.1021/jm201591k
BindingDB Entry DOI: 10.7270/Q2K938JM
More data for this
Ligand-Target Pair