BDBM50386424 CHEMBL2047528

SMILES: CN(CCCOc1ccc2ccc(=O)oc2c1)Cc1cccc(OC(=O)NCCCCCc2ccccc2)c1

InChI Key: InChIKey=LPCKLAOPKGFZKH-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50386424   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50386424 (CHEMBL2047528) Show SMILES CN(CCCOc1ccc2ccc(=O)oc2c1)Cc1cccc(OC(=O)NCCCCCc2ccccc2)c1 Show InChI InChI=1S/C32H36N2O5/c1-34(20-9-21-37-28-17-15-27-16-18-31(35)39-30(27)23-28)24-26-13-8-14-29(22-26)38-32(36)33-19-7-3-6-12-25-10-4-2-5-11-25/h2,4-5,8,10-11,13-18,22-23H,3,6-7,9,12,19-21,24H2,1H3,(H,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	183	n/a	n/a	n/a	n/a	9.0	n/a
Alma Mater Studiorum University of Bologna Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane at pH 9 using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 10 mins followed by substrate ...				J Med Chem 59: 6387-406 (2016) BindingDB Entry DOI: 10.7270/Q21G0P6Q
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50386424 (CHEMBL2047528) Show SMILES CN(CCCOc1ccc2ccc(=O)oc2c1)Cc1cccc(OC(=O)NCCCCCc2ccccc2)c1 Show InChI InChI=1S/C32H36N2O5/c1-34(20-9-21-37-28-17-15-27-16-18-31(35)39-30(27)23-28)24-26-13-8-14-29(22-26)38-32(36)33-19-7-3-6-12-25-10-4-2-5-11-25/h2,4-5,8,10-11,13-18,22-23H,3,6-7,9,12,19-21,24H2,1H3,(H,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	7.4	n/a
Alma Mater Studiorum University of Bologna Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane at pH 7.4 using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 10 mins followed by substrat...				J Med Chem 59: 6387-406 (2016) BindingDB Entry DOI: 10.7270/Q21G0P6Q
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50386424 (CHEMBL2047528) Show SMILES CN(CCCOc1ccc2ccc(=O)oc2c1)Cc1cccc(OC(=O)NCCCCCc2ccccc2)c1 Show InChI InChI=1S/C32H36N2O5/c1-34(20-9-21-37-28-17-15-27-16-18-31(35)39-30(27)23-28)24-26-13-8-14-29(22-26)38-32(36)33-19-7-3-6-12-25-10-4-2-5-11-25/h2,4-5,8,10-11,13-18,22-23H,3,6-7,9,12,19-21,24H2,1H3,(H,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measur...				ACS Med Chem Lett 3: 182-186 (2012) Article DOI: 10.1021/ml200313p BindingDB Entry DOI: 10.7270/Q29W0GJB
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50386424 (CHEMBL2047528) Show SMILES CN(CCCOc1ccc2ccc(=O)oc2c1)Cc1cccc(OC(=O)NCCCCCc2ccccc2)c1 Show InChI InChI=1S/C32H36N2O5/c1-34(20-9-21-37-28-17-15-27-16-18-31(35)39-30(27)23-28)24-26-13-8-14-29(22-26)38-32(36)33-19-7-3-6-12-25-10-4-2-5-11-25/h2,4-5,8,10-11,13-18,22-23H,3,6-7,9,12,19-21,24H2,1H3,(H,33,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide after 30 mins				ACS Med Chem Lett 3: 182-186 (2012) Article DOI: 10.1021/ml200313p BindingDB Entry DOI: 10.7270/Q29W0GJB
					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50386424 (CHEMBL2047528) Show SMILES CN(CCCOc1ccc2ccc(=O)oc2c1)Cc1cccc(OC(=O)NCCCCCc2ccccc2)c1 Show InChI InChI=1S/C32H36N2O5/c1-34(20-9-21-37-28-17-15-27-16-18-31(35)39-30(27)23-28)24-26-13-8-14-29(22-26)38-32(36)33-19-7-3-6-12-25-10-4-2-5-11-25/h2,4-5,8,10-11,13-18,22-23H,3,6-7,9,12,19-21,24H2,1H3,(H,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 120 mins before substrate addition by Ellman's meth...				ACS Med Chem Lett 3: 182-186 (2012) Article DOI: 10.1021/ml200313p BindingDB Entry DOI: 10.7270/Q29W0GJB
					More data for this Ligand-Target Pair
Cholinesterases (Homo sapiens (Human))	BDBM50386424 (CHEMBL2047528) Show SMILES CN(CCCOc1ccc2ccc(=O)oc2c1)Cc1cccc(OC(=O)NCCCCCc2ccccc2)c1 Show InChI InChI=1S/C32H36N2O5/c1-34(20-9-21-37-28-17-15-27-16-18-31(35)39-30(27)23-28)24-26-13-8-14-29(22-26)38-32(36)33-19-7-3-6-12-25-10-4-2-5-11-25/h2,4-5,8,10-11,13-18,22-23H,3,6-7,9,12,19-21,24H2,1H3,(H,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.57	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 15 mins before substrate addition by Ellman's method				ACS Med Chem Lett 3: 182-186 (2012) Article DOI: 10.1021/ml200313p BindingDB Entry DOI: 10.7270/Q29W0GJB
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50386424 (CHEMBL2047528) Show SMILES CN(CCCOc1ccc2ccc(=O)oc2c1)Cc1cccc(OC(=O)NCCCCCc2ccccc2)c1 Show InChI InChI=1S/C32H36N2O5/c1-34(20-9-21-37-28-17-15-27-16-18-31(35)39-30(27)23-28)24-26-13-8-14-29(22-26)38-32(36)33-19-7-3-6-12-25-10-4-2-5-11-25/h2,4-5,8,10-11,13-18,22-23H,3,6-7,9,12,19-21,24H2,1H3,(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH in assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measured...				ACS Med Chem Lett 3: 182-186 (2012) Article DOI: 10.1021/ml200313p BindingDB Entry DOI: 10.7270/Q29W0GJB
					More data for this Ligand-Target Pair