Found 4 hits for monomerid = 50387536 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50387536
(CHEMBL2057362)Show SMILES Cc1noc(C)c1CCNC(=O)Nc1nc2ccc(cn2n1)-c1cncc(c1)S(=O)(=O)NC(C)(C)C Show InChI InChI=1S/C23H28N8O4S/c1-14-19(15(2)35-29-14)8-9-25-22(32)27-21-26-20-7-6-16(13-31(20)28-21)17-10-18(12-24-11-17)36(33,34)30-23(3,4)5/h6-7,10-13,30H,8-9H2,1-5H3,(H2,25,27,28,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50387536
(CHEMBL2057362)Show SMILES Cc1noc(C)c1CCNC(=O)Nc1nc2ccc(cn2n1)-c1cncc(c1)S(=O)(=O)NC(C)(C)C Show InChI InChI=1S/C23H28N8O4S/c1-14-19(15(2)35-29-14)8-9-25-22(32)27-21-26-20-7-6-16(13-31(20)28-21)17-10-18(12-24-11-17)36(33,34)30-23(3,4)5/h6-7,10-13,30H,8-9H2,1-5H3,(H2,25,27,28,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kbeta in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50387536
(CHEMBL2057362)Show SMILES Cc1noc(C)c1CCNC(=O)Nc1nc2ccc(cn2n1)-c1cncc(c1)S(=O)(=O)NC(C)(C)C Show InChI InChI=1S/C23H28N8O4S/c1-14-19(15(2)35-29-14)8-9-25-22(32)27-21-26-20-7-6-16(13-31(20)28-21)17-10-18(12-24-11-17)36(33,34)30-23(3,4)5/h6-7,10-13,30H,8-9H2,1-5H3,(H2,25,27,28,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50387536
(CHEMBL2057362)Show SMILES Cc1noc(C)c1CCNC(=O)Nc1nc2ccc(cn2n1)-c1cncc(c1)S(=O)(=O)NC(C)(C)C Show InChI InChI=1S/C23H28N8O4S/c1-14-19(15(2)35-29-14)8-9-25-22(32)27-21-26-20-7-6-16(13-31(20)28-21)17-10-18(12-24-11-17)36(33,34)30-23(3,4)5/h6-7,10-13,30H,8-9H2,1-5H3,(H2,25,27,28,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
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