Found 4 hits for monomerid = 50387537 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50387537
(CHEMBL2057364)Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(NC(=O)NCCn3cccn3)nn2c1 Show InChI InChI=1S/C21H25N9O3S/c1-21(2,3)28-34(32,33)17-11-16(12-22-13-17)15-5-6-18-25-19(27-30(18)14-15)26-20(31)23-8-10-29-9-4-7-24-29/h4-7,9,11-14,28H,8,10H2,1-3H3,(H2,23,26,27,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50387537
(CHEMBL2057364)Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(NC(=O)NCCn3cccn3)nn2c1 Show InChI InChI=1S/C21H25N9O3S/c1-21(2,3)28-34(32,33)17-11-16(12-22-13-17)15-5-6-18-25-19(27-30(18)14-15)26-20(31)23-8-10-29-9-4-7-24-29/h4-7,9,11-14,28H,8,10H2,1-3H3,(H2,23,26,27,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50387537
(CHEMBL2057364)Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(NC(=O)NCCn3cccn3)nn2c1 Show InChI InChI=1S/C21H25N9O3S/c1-21(2,3)28-34(32,33)17-11-16(12-22-13-17)15-5-6-18-25-19(27-30(18)14-15)26-20(31)23-8-10-29-9-4-7-24-29/h4-7,9,11-14,28H,8,10H2,1-3H3,(H2,23,26,27,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kbeta in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50387537
(CHEMBL2057364)Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(NC(=O)NCCn3cccn3)nn2c1 Show InChI InChI=1S/C21H25N9O3S/c1-21(2,3)28-34(32,33)17-11-16(12-22-13-17)15-5-6-18-25-19(27-30(18)14-15)26-20(31)23-8-10-29-9-4-7-24-29/h4-7,9,11-14,28H,8,10H2,1-3H3,(H2,23,26,27,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of PI3Kalpha in human HL60 cell lysate by kinobead assay |
Bioorg Med Chem Lett 22: 4546-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN |
More data for this
Ligand-Target Pair | |
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