Found 3 hits for monomerid = 50389994 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50389994
(CHEMBL2071274)Show SMILES NC(=O)[C@H]1[C@H]2C[C@H](C=C2)[C@H]1Nc1nc(Nc2cnn(CCN3CCOCC3)c2)ncc1Cl |r,c:7| Show InChI InChI=1S/C21H27ClN8O2/c22-16-11-24-21(26-15-10-25-30(12-15)4-3-29-5-7-32-8-6-29)28-20(16)27-18-14-2-1-13(9-14)17(18)19(23)31/h1-2,10-14,17-18H,3-9H2,(H2,23,31)(H2,24,26,27,28)/t13-,14+,17+,18-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human KDR autophosphorylation expressed in mouse NIH/3T3 cells |
Bioorg Med Chem Lett 22: 4750-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.067 BindingDB Entry DOI: 10.7270/Q20C4WTF |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50389994
(CHEMBL2071274)Show SMILES NC(=O)[C@H]1[C@H]2C[C@H](C=C2)[C@H]1Nc1nc(Nc2cnn(CCN3CCOCC3)c2)ncc1Cl |r,c:7| Show InChI InChI=1S/C21H27ClN8O2/c22-16-11-24-21(26-15-10-25-30(12-15)4-3-29-5-7-32-8-6-29)28-20(16)27-18-14-2-1-13(9-14)17(18)19(23)31/h1-2,10-14,17-18H,3-9H2,(H2,23,31)(H2,24,26,27,28)/t13-,14+,17+,18-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of KDR by HTRF analysis in presence of 1 mM ATP |
Bioorg Med Chem Lett 22: 4750-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.067 BindingDB Entry DOI: 10.7270/Q20C4WTF |
More data for this Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50389994
(CHEMBL2071274)Show SMILES NC(=O)[C@H]1[C@H]2C[C@H](C=C2)[C@H]1Nc1nc(Nc2cnn(CCN3CCOCC3)c2)ncc1Cl |r,c:7| Show InChI InChI=1S/C21H27ClN8O2/c22-16-11-24-21(26-15-10-25-30(12-15)4-3-29-5-7-32-8-6-29)28-20(16)27-18-14-2-1-13(9-14)17(18)19(23)31/h1-2,10-14,17-18H,3-9H2,(H2,23,31)(H2,24,26,27,28)/t13-,14+,17+,18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP |
Bioorg Med Chem Lett 22: 4750-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.067 BindingDB Entry DOI: 10.7270/Q20C4WTF |
More data for this Ligand-Target Pair | |