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SMILES: Nc1nc(nc2n(Cc3ccc4OCCc4c3)nnc12)C1CC1

InChI Key: InChIKey=AVFBPEQFYFCOSS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50390378   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B


(Homo sapiens (Human))		BDBM50390378
PNG
(CHEMBL2070919)
Show SMILES Nc1nc(nc2n(Cc3ccc4OCCc4c3)nnc12)C1CC1
Show InChI InChI=1S/C16H16N6O/c17-14-13-16(19-15(18-14)10-2-3-10)22(21-20-13)8-9-1-4-12-11(7-9)5-6-23-12/h1,4,7,10H,2-3,5-6,8H2,(H2,17,18,19)
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Article
PubMed
n/an/a 17.1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells

Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair