BDBM50391978 CHEMBL2152287

SMILES: Nc1cc(NS(=O)(=O)c2ccc(F)cc2F)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1

InChI Key: InChIKey=MNRXZGDQXJKRRE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50391978   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50391978 (CHEMBL2152287) Show SMILES Nc1cc(NS(=O)(=O)c2ccc(F)cc2F)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C24H17F2N5O2S/c25-17-1-2-23(22(26)10-17)34(32,33)31-19-8-15(7-18(27)11-19)16-9-20-21(13-30-24(20)29-12-16)14-3-5-28-6-4-14/h1-13,31H,27H2,(H,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.97	n/a	n/a	n/a	n/a	n/a	n/a
Korea Advanced Institute of Science and Technology (KAIST) Curated by ChEMBL					Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate				J Med Chem 55: 5337-49 (2012) Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3
					More data for this Ligand-Target Pair