BindingDB PrimarySearch

BDBM50392512 CHEMBL2152165

SMILES: FC(F)C(F)(F)Oc1cc(F)cc(c1)[C@](Cc1ccccc1)(NC(=O)NC1CCCC1)c1ccc(Cl)cn1

InChI Key: InChIKey=DLEGYAJVPJEXJD-SANMLTNESA-N

Data: 10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50392512
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cholesteryl ester transfer protein (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of CETP-mediated [3H]cholesteryl ester transfer activity in human plasma after 2.5 hrs by scintillation counter				J Med Chem 55: 6162-75 (2012) Article DOI: 10.1021/jm300611v BindingDB Entry DOI: 10.7270/Q2KH0PF5
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
Cholesteryl ester transfer protein (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human recombinant CETP-mediated [3H]cholesteryl ester transfer from HDL to biotinylated LDL by scintillation proximity assay				J Med Chem 55: 6162-75 (2012) Article DOI: 10.1021/jm300611v BindingDB Entry DOI: 10.7270/Q2KH0PF5
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
Cholesteryl ester transfer protein (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of CETP in human whole plasma using [3H]-CE/HDL after 10 mins				Bioorg Med Chem Lett 24: 860-4 (2014) Article DOI: 10.1016/j.bmcl.2013.12.088 BindingDB Entry DOI: 10.7270/Q2WM1FW9
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair
Cholesteryl ester transfer protein (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of human recombinant CETP using [3H]-CE/HDL by scintillation proximity assay				Bioorg Med Chem Lett 24: 860-4 (2014) Article DOI: 10.1016/j.bmcl.2013.12.088 BindingDB Entry DOI: 10.7270/Q2WM1FW9
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair
Cholesteryl ester transfer protein (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of CETP in human plasma using [3H]cholesterol ester/HDL as substrate after 10 mins by scintillation counting				Bioorg Med Chem Lett 22: 6503-8 (2012) Article DOI: 10.1016/j.bmcl.2012.08.011 BindingDB Entry DOI: 10.7270/Q2XP761G
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of CYP2C19 (unknown origin)				Bioorg Med Chem Lett 24: 860-4 (2014) Article DOI: 10.1016/j.bmcl.2013.12.088 BindingDB Entry DOI: 10.7270/Q2WM1FW9
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of CYP2C9 (unknown origin)				Bioorg Med Chem Lett 24: 860-4 (2014) Article DOI: 10.1016/j.bmcl.2013.12.088 BindingDB Entry DOI: 10.7270/Q2WM1FW9
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 1A (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of CYP1A2 (unknown origin)				Bioorg Med Chem Lett 24: 860-4 (2014) Article DOI: 10.1016/j.bmcl.2013.12.088 BindingDB Entry DOI: 10.7270/Q2WM1FW9
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair
Cholesteryl ester transfer protein (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of human recombinant CETP using [3H]cholesterol ester/HDL as substrate by scintillation proximity assay				Bioorg Med Chem Lett 22: 6503-8 (2012) Article DOI: 10.1016/j.bmcl.2012.08.011 BindingDB Entry DOI: 10.7270/Q2XP761G
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50392512 (CHEMBL2152165) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of CYP2D6 (unknown origin)				Bioorg Med Chem Lett 24: 860-4 (2014) Article DOI: 10.1016/j.bmcl.2013.12.088 BindingDB Entry DOI: 10.7270/Q2WM1FW9
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair