Found 14 hits for monomerid = 50393642 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Tech
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SphK2 using NBD-sphingosine as substrate after 2 hrs by HPLC analysis |
Bioorg Med Chem Lett 22: 6817-20 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.050 BindingDB Entry DOI: 10.7270/Q22Z16MT |
More data for this Ligand-Target Pair | |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation counting |
Bioorg Med Chem Lett 23: 4608-16 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.030 BindingDB Entry DOI: 10.7270/Q2736SB3 |
More data for this Ligand-Target Pair | |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
500 University Drive
Curated by ChEMBL
| Assay Description Competitive inhibition of human recombinant SphK2 assessed as NBD-S1P formation using NBD-Sph as substrate by HPLC analysis |
J Med Chem 57: 5509-24 (2014)
Article DOI: 10.1021/jm4011687 BindingDB Entry DOI: 10.7270/Q2474CF5 |
More data for this Ligand-Target Pair | |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Tech
Curated by ChEMBL
| Assay Description Inhibition of human recombinant SphK2 expressed in Sf9 cells assessed as radiolabeled products using 10 uM sphingosine and 10 uM gamma[32P]ATP by liq... |
J Med Chem 58: 1879-99 (2015)
Article DOI: 10.1021/jm501760d BindingDB Entry DOI: 10.7270/Q2PK0HV3 |
More data for this Ligand-Target Pair | |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Peking Union Medical College and Chinese Academy of Medical Sciences
Curated by ChEMBL
| Assay Description Inhibition of SPHK2 (unknown origin) |
Bioorg Med Chem 24: 3218-30 (2016)
BindingDB Entry DOI: 10.7270/Q2377BN8 |
More data for this Ligand-Target Pair | |
Sphingosine kinase 2
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Sphingosine kinase 2
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Heriot-Watt University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using NBD-Sph as substrate m... |
J Med Chem 62: 3658-3676 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00162 |
More data for this Ligand-Target Pair | |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of recombinant human SPHK2 using sphingosine as substrate by ADP-Quest assay |
J Med Chem 60: 3933-3957 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00233 BindingDB Entry DOI: 10.7270/Q2DJ5J3Q |
More data for this Ligand-Target Pair | |
Sphingosine kinase 2
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sphingosine kinase 2
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The City University of New York
Curated by ChEMBL
| Assay Description Inhibition of SK2 (unknown origin) |
Medchemcomm 4: (2013)
Article DOI: 10.1039/c3md00201b BindingDB Entry DOI: 10.7270/Q2736TWP |
More data for this Ligand-Target Pair | |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| PubMed
| 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville Campus)
Curated by ChEMBL
| Assay Description Inhibition of SK2 (unknown origin) |
J Med Chem 59: 965-84 (2016)
BindingDB Entry DOI: 10.7270/Q2WW7KJH |
More data for this Ligand-Target Pair | |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| PubMed
| 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Tech
Curated by ChEMBL
| Assay Description Inhibition of SphK2 (unknown origin) |
Bioorg Med Chem Lett 25: 4956-60 (2015)
BindingDB Entry DOI: 10.7270/Q28G8NHJ |
More data for this Ligand-Target Pair | |
Sphingosine kinase 1 (SPHK1)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: hohno@pharm.kyoto-u.ac.jp.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human SphK1 using NBD-sphingosine as substrate after 2 hrs in presence of ATP by HPLC method |
Bioorg Med Chem 25: 3046-3052 (2017)
Article DOI: 10.1016/j.bmc.2017.03.059 BindingDB Entry DOI: 10.7270/Q2XD144Z |
More data for this Ligand-Target Pair | |
Sphingosine kinase types 2 (SphK2)
(Homo sapiens (Human)) | BDBM50393642
![PNG](/data/jpeg/tenK5039/BindingDB_50393642.png) (CHEMBL2158685)Show SMILES Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| Show InChI InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) | UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: hohno@pharm.kyoto-u.ac.jp.
Curated by ChEMBL
| Assay Description Inhibition of recombinant human SphK2 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate after 20 mins in presence ... |
Bioorg Med Chem 25: 3046-3052 (2017)
Article DOI: 10.1016/j.bmc.2017.03.059 BindingDB Entry DOI: 10.7270/Q2XD144Z |
More data for this Ligand-Target Pair | |