BDBM50394766 CHEMBL2163376

SMILES: Cc1cccc(c1)C1=N\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C(=O)O1

InChI Key: InChIKey=JAVHHMSMRLOMPB-PDGQHHTCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50394766   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50394766 (CHEMBL2163376) Show SMILES Cc1cccc(c1)C1=N\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C(=O)O1 |t:8| Show InChI InChI=1S/C21H14ClNO3/c1-13-4-2-6-15(10-13)20-23-18(21(24)26-20)12-17-8-9-19(25-17)14-5-3-7-16(22)11-14/h2-12H,1H3/b18-12-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL2-DE3 incubated 10 mins before substrate addition by fluorescence spectrophotom...				J Med Chem 55: 2597-605 (2012) Article DOI: 10.1021/jm201497k BindingDB Entry DOI: 10.7270/Q20P115J
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50394766 (CHEMBL2163376) Show SMILES Cc1cccc(c1)C1=N\C(=C/c2ccc(o2)-c2cccc(Cl)c2)C(=O)O1 |t:8| Show InChI InChI=1S/C21H14ClNO3/c1-13-4-2-6-15(10-13)20-23-18(21(24)26-20)12-17-8-9-19(25-17)14-5-3-7-16(22)11-14/h2-12H,1H3/b18-12-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of human 5-LOX in A23187-induced human whole blood assessed as reduction in LTB4 production pre-incubated for 20 mins before A23187 additi...				J Med Chem 55: 2597-605 (2012) Article DOI: 10.1021/jm201497k BindingDB Entry DOI: 10.7270/Q20P115J
					More data for this Ligand-Target Pair