BindingDB PrimarySearch

BDBM50396625 CHEMBL2171934::US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-3-methyl-2-phenylquinoline

SMILES: Cc1c(nc2ccccc2c1N1CC(C)(C)c2ccc(cc12)N1CCOCC1)-c1ccccc1

InChI Key: InChIKey=ACWBFWBJDDHSBS-UHFFFAOYSA-N

Data: 1 KI 3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50396625
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50396625 (CHEMBL2171934 \| US8765940, 4-(3,3-dimethyl-6-(4-mo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	85.4	n/a	n/a	n/a	n/a	n/a	n/a	7.0	n/a
Amgen Inc. US Patent					Assay Description A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...				US Patent US8765940 (2014) BindingDB Entry DOI: 10.7270/Q2WW7G94
Amgen Inc. US Patent					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50396625 (CHEMBL2171934 \| US8765940, 4-(3,3-dimethyl-6-(4-mo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assay				J Med Chem 55: 7667-85 (2012) Article DOI: 10.1021/jm300679u BindingDB Entry DOI: 10.7270/Q2J38TQ0
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50396625 (CHEMBL2171934 \| US8765940, 4-(3,3-dimethyl-6-(4-mo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assay				J Med Chem 55: 7667-85 (2012) Article DOI: 10.1021/jm300679u BindingDB Entry DOI: 10.7270/Q2J38TQ0
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50396625 (CHEMBL2171934 \| US8765940, 4-(3,3-dimethyl-6-(4-mo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human B cells assessed as inhibition of anti-IgM/CD40L-induced proliferation after 72 hrs by [3H]thymidine incorporation a...				J Med Chem 55: 7667-85 (2012) Article DOI: 10.1021/jm300679u BindingDB Entry DOI: 10.7270/Q2J38TQ0
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair