BDBM50397979 CHEMBL2180418::US8927738, 5,8-Dimethyl-2-[2-(1-methyl-2-thiophen-2-yl-1H-imidazol-4-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine

SMILES: Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3cccs3)nn12

InChI Key: InChIKey=QSNNSBMZPOPCLI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50397979   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50397979 (CHEMBL2180418 | US8927738, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3cccs3)nn12 Show InChI InChI=1S/C17H18N6S/c1-11-9-18-12(2)16-20-15(21-23(11)16)7-6-13-10-22(3)17(19-13)14-5-4-8-24-14/h4-5,8-10H,6-7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PDE10A				J Med Chem 55: 7299-331 (2012) Article DOI: 10.1021/jm3004976 BindingDB Entry DOI: 10.7270/Q2C24XJK
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50397979 (CHEMBL2180418 | US8927738, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3cccs3)nn12 Show InChI InChI=1S/C17H18N6S/c1-11-9-18-12(2)16-20-15(21-23(11)16)7-6-13-10-22(3)17(19-13)14-5-4-8-24-14/h4-5,8-10H,6-7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair