BDBM50397989 CHEMBL2180805::US8759532, 32
SMILES: C1CN(CCO1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1
InChI Key: InChIKey=IYBQVHPASLEZNE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50397989 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50397989
(CHEMBL2180805 | US8759532, 32)Show SMILES C1CN(CCO1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C22H20N4O2S/c1-2-6-20-18(4-1)25-22(29-20)24-16-7-9-17(10-8-16)28-21-19(5-3-11-23-21)26-12-14-27-15-13-26/h1-11H,12-15H2,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
J Med Chem 55: 7299-331 (2012)
Article DOI: 10.1021/jm3004976 BindingDB Entry DOI: 10.7270/Q2C24XJK |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50397989
(CHEMBL2180805 | US8759532, 32)Show SMILES C1CN(CCO1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C22H20N4O2S/c1-2-6-20-18(4-1)25-22(29-20)24-16-7-9-17(10-8-16)28-21-19(5-3-11-23-21)26-12-14-27-15-13-26/h1-11H,12-15H2,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 0.962 | n/a | n/a | n/a | n/a | n/a | 25 |
Amgen Inc.
US Patent
| Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die... |
US Patent US8759532 (2014)
BindingDB Entry DOI: 10.7270/Q25D8QHR |
More data for this Ligand-Target Pair | |