BDBM50397993 CHEMBL2180406

SMILES: CCN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccn2cc(nc2n1)-c1ccccc1

InChI Key: InChIKey=UIRKZMHTWRSYJH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50397993   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50397993 (CHEMBL2180406) Show SMILES CCN(C)C(=O)c1cnn(C)c1C(=O)Nc1ccn2cc(nc2n1)-c1ccccc1 Show InChI InChI=1S/C21H21N7O2/c1-4-26(2)20(30)15-12-22-27(3)18(15)19(29)24-17-10-11-28-13-16(23-21(28)25-17)14-8-6-5-7-9-14/h5-13H,4H2,1-3H3,(H,23,24,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assay				J Med Chem 55: 7299-331 (2012) Article DOI: 10.1021/jm3004976 BindingDB Entry DOI: 10.7270/Q2C24XJK
					More data for this Ligand-Target Pair