BDBM50398357 CHEMBL2177362

SMILES: C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)c(F)c3)c12

InChI Key: InChIKey=PSNRYUGYGZTZSY-ZWDAVXSWSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50398357   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50398357 (CHEMBL2177362) Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)c(F)c3)c12 |r| Show InChI InChI=1S/C26H33ClFN5O3/c1-16-12-22(34)24-23(16)25(31-15-30-24)32-6-8-33(9-7-32)26(35)19(14-29-18-4-10-36-11-5-18)17-2-3-20(27)21(28)13-17/h2-3,13,15-16,18-19,22,29,34H,4-12,14H2,1H3/t16-,19-,22-/m1/s1	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...				J Med Chem 55: 8110-27 (2012) Article DOI: 10.1021/jm301024w BindingDB Entry DOI: 10.7270/Q20P1160
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50398357 (CHEMBL2177362) Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)c(F)c3)c12 |r| Show InChI InChI=1S/C26H33ClFN5O3/c1-16-12-22(34)24-23(16)25(31-15-30-24)32-6-8-33(9-7-32)26(35)19(14-29-18-4-10-36-11-5-18)17-2-3-20(27)21(28)13-17/h2-3,13,15-16,18-19,22,29,34H,4-12,14H2,1H3/t16-,19-,22-/m1/s1	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...				J Med Chem 55: 8110-27 (2012) Article DOI: 10.1021/jm301024w BindingDB Entry DOI: 10.7270/Q20P1160
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM50398357 (CHEMBL2177362) Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)c(F)c3)c12 |r| Show InChI InChI=1S/C26H33ClFN5O3/c1-16-12-22(34)24-23(16)25(31-15-30-24)32-6-8-33(9-7-32)26(35)19(14-29-18-4-10-36-11-5-18)17-2-3-20(27)21(28)13-17/h2-3,13,15-16,18-19,22,29,34H,4-12,14H2,1H3/t16-,19-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...				J Med Chem 55: 8110-27 (2012) Article DOI: 10.1021/jm301024w BindingDB Entry DOI: 10.7270/Q20P1160
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50398357 (CHEMBL2177362) Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)c(F)c3)c12 |r| Show InChI InChI=1S/C26H33ClFN5O3/c1-16-12-22(34)24-23(16)25(31-15-30-24)32-6-8-33(9-7-32)26(35)19(14-29-18-4-10-36-11-5-18)17-2-3-20(27)21(28)13-17/h2-3,13,15-16,18-19,22,29,34H,4-12,14H2,1H3/t16-,19-,22-/m1/s1	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...				J Med Chem 55: 8110-27 (2012) Article DOI: 10.1021/jm301024w BindingDB Entry DOI: 10.7270/Q20P1160
					More data for this Ligand-Target Pair