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BDBM50399082 CHEMBL2179325

SMILES: FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(C1)c1ccccc1

InChI Key: InChIKey=KOBHXKVGKGEKFN-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399082   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50399082
PNG
(CHEMBL2179325)
Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(C1)c1ccccc1
Show InChI InChI=1S/C21H21F3N4/c22-21(23,24)19-17(27-10-8-16(13-27)15-4-2-1-3-5-15)9-11-28-18(12-14-6-7-14)25-26-20(19)28/h1-5,9,11,14,16H,6-8,10,12-13H2
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.23E+3n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu2R expressed in CHO cells incubated for 30 mins by [35S]GTPgammaS binding assay

J Med Chem 55: 8770-89 (2012)


Article DOI: 10.1021/jm3010724
BindingDB Entry DOI: 10.7270/Q26111FF
More data for this
Ligand-Target Pair