BDBM50399086 CHEMBL2179321

SMILES: CCCCc1nnc2c(c(ccn12)N1CCC(CC1)c1ccccc1)C(F)(F)F

InChI Key: InChIKey=OVHBEKVNHLICMZ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399086   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50399086 (CHEMBL2179321) Show SMILES CCCCc1nnc2c(c(ccn12)N1CCC(CC1)c1ccccc1)C(F)(F)F Show InChI InChI=1S/C22H25F3N4/c1-2-3-9-19-26-27-21-20(22(23,24)25)18(12-15-29(19)21)28-13-10-17(11-14-28)16-7-5-4-6-8-16/h4-8,12,15,17H,2-3,9-11,13-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu2R expressed in CHO cells incubated for 30 mins by [35S]GTPgammaS binding assay				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
					More data for this Ligand-Target Pair