BDBM50399087 CHEMBL2179320

SMILES: CCc1nnc2c(c(ccn12)N1CCC(CC1)c1ccccc1)C(F)(F)F

InChI Key: InChIKey=PMHJRMIXYKVQTO-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399087   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50399087 (CHEMBL2179320) Show SMILES CCc1nnc2c(c(ccn12)N1CCC(CC1)c1ccccc1)C(F)(F)F Show InChI InChI=1S/C20H21F3N4/c1-2-17-24-25-19-18(20(21,22)23)16(10-13-27(17)19)26-11-8-15(9-12-26)14-6-4-3-5-7-14/h3-7,10,13,15H,2,8-9,11-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	116	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu2R expressed in CHO cells incubated for 30 mins by [35S]GTPgammaS binding assay				J Med Chem 55: 8770-89 (2012) Article DOI: 10.1021/jm3010724 BindingDB Entry DOI: 10.7270/Q26111FF
					More data for this Ligand-Target Pair