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SMILES: FC(F)(F)Cc1nnc2c(Cl)c(ccn12)N1CCC(F)(CC1)c1ccccc1

InChI Key: InChIKey=TUTUFABMXLXQMU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50399091   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50399091
PNG
(CHEMBL2179316)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(ccn12)N1CCC(F)(CC1)c1ccccc1
Show InChI InChI=1S/C19H17ClF4N4/c20-16-14(6-9-28-15(12-19(22,23)24)25-26-17(16)28)27-10-7-18(21,8-11-27)13-4-2-1-3-5-13/h1-6,9H,7-8,10-12H2
PDB

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 116n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu2R expressed in CHO cells incubated for 30 mins by [35S]GTPgammaS binding assay

J Med Chem 55: 8770-89 (2012)


Article DOI: 10.1021/jm3010724
BindingDB Entry DOI: 10.7270/Q26111FF
More data for this
Ligand-Target Pair