Found 4 hits for monomerid = 50402947 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50402947
![PNG](/data/jpeg/tenK5040/BindingDB_50402947.png) (CHEMBL2206226)Show SMILES OC(=O)C1CCN(CC1)c1nccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C23H21N5O3S/c29-22(30)15-9-13-28(14-10-15)20-21(25-12-11-24-20)31-17-7-5-16(6-8-17)26-23-27-18-3-1-2-4-19(18)32-23/h1-8,11-12,15H,9-10,13-14H2,(H,26,27)(H,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.82 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PDE10A2 using FAM-cAMP as substrate incubated for 60 mins prior to substrate addition measured after 90 mins by IMAP-FRET assay |
Bioorg Med Chem Lett 22: 7371-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.078 BindingDB Entry DOI: 10.7270/Q2GB257C |
More data for this Ligand-Target Pair | |
Homo sapiens phosphodiesterase 2A (PDE2A)
(Homo sapiens (Human)) | BDBM50402947
![PNG](/data/jpeg/tenK5040/BindingDB_50402947.png) (CHEMBL2206226)Show SMILES OC(=O)C1CCN(CC1)c1nccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C23H21N5O3S/c29-22(30)15-9-13-28(14-10-15)20-21(25-12-11-24-20)31-17-7-5-16(6-8-17)26-23-27-18-3-1-2-4-19(18)32-23/h1-8,11-12,15H,9-10,13-14H2,(H,26,27)(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE2A |
Bioorg Med Chem Lett 22: 7371-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.078 BindingDB Entry DOI: 10.7270/Q2GB257C |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50402947
![PNG](/data/jpeg/tenK5040/BindingDB_50402947.png) (CHEMBL2206226)Show SMILES OC(=O)C1CCN(CC1)c1nccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C23H21N5O3S/c29-22(30)15-9-13-28(14-10-15)20-21(25-12-11-24-20)31-17-7-5-16(6-8-17)26-23-27-18-3-1-2-4-19(18)32-23/h1-8,11-12,15H,9-10,13-14H2,(H,26,27)(H,29,30) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE4D |
Bioorg Med Chem Lett 22: 7371-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.078 BindingDB Entry DOI: 10.7270/Q2GB257C |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3 (PDE3)
(Homo sapiens (Human)) | BDBM50402947
![PNG](/data/jpeg/tenK5040/BindingDB_50402947.png) (CHEMBL2206226)Show SMILES OC(=O)C1CCN(CC1)c1nccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C23H21N5O3S/c29-22(30)15-9-13-28(14-10-15)20-21(25-12-11-24-20)31-17-7-5-16(6-8-17)26-23-27-18-3-1-2-4-19(18)32-23/h1-8,11-12,15H,9-10,13-14H2,(H,26,27)(H,29,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PDE3A using FAM-cAMP as substrate incubated for 60 mins prior to substrate addition measured after 90 mins by IMAP-FRET assay |
Bioorg Med Chem Lett 22: 7371-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.078 BindingDB Entry DOI: 10.7270/Q2GB257C |
More data for this Ligand-Target Pair | |