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SMILES: OC(=O)CC(=O)CP(O)(=O)C=CC1=C(c2ccccc2C11CCCC1)c1ccc(F)cc1

InChI Key: InChIKey=OYKDVBAMEAOLIC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50406122   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM50406122
PNG
(CHEMBL318784)
Show SMILES OC(=O)CC(=O)CP(O)(=O)C=CC1=C(c2ccccc2C11CCCC1)c1ccc(F)cc1 |w:10.9,t:12|
Show InChI InChI=1S/C25H24FO5P/c26-18-9-7-17(8-10-18)24-20-5-1-2-6-21(20)25(12-3-4-13-25)22(24)11-14-32(30,31)16-19(27)15-23(28)29/h1-2,5-11,14H,3-4,12-13,15-16H2,(H,28,29)(H,30,31)
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PC cid
PC sid
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Similars
PubMed
n/an/a 2.80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat microsomal HMG-CoA reductase activity by 50%

J Med Chem 33: 2952-6 (1990)


BindingDB Entry DOI: 10.7270/Q22Z16Q5
More data for this
Ligand-Target Pair