Found 4 hits for monomerid = 50411961 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
P-glycoprotein 1
(Homo sapiens (Human)) | BDBM50411961
![PNG](/data/jpeg/tenK5041/BindingDB_50411961.png) (CHEMBL261618)Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1ccc(CCN2CCc3ccccc3C2)cc1 Show InChI InChI=1S/C24H23N3O3/c28-24(20-7-11-23(12-8-20)27(29)30)25-22-9-5-18(6-10-22)13-15-26-16-14-19-3-1-2-4-21(19)17-26/h1-12H,13-17H2,(H,25,28) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description Inhibition of human Pgp in A2780 cells after 30 mins by Hoechst 33342 assay |
Bioorg Med Chem 16: 2448-62 (2008)
Article DOI: 10.1016/j.bmc.2007.11.057 BindingDB Entry DOI: 10.7270/Q2QN67PT |
More data for this Ligand-Target Pair | |
Multidrug resistance protein 1/Multidrug resistance associated protein 1
(Homo sapiens (Human)) | BDBM50411961
![PNG](/data/jpeg/tenK5041/BindingDB_50411961.png) (CHEMBL261618)Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1ccc(CCN2CCc3ccccc3C2)cc1 Show InChI InChI=1S/C24H23N3O3/c28-24(20-7-11-23(12-8-20)27(29)30)25-22-9-5-18(6-10-22)13-15-26-16-14-19-3-1-2-4-21(19)17-26/h1-12H,13-17H2,(H,25,28) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description Inhibition of P-glycoprotein-mediated multidrug resistance in adriamycin-resistant human A2780/ADR cells by calcein AM assay |
Bioorg Med Chem 17: 2524-35 (2009)
Article DOI: 10.1016/j.bmc.2009.01.072 BindingDB Entry DOI: 10.7270/Q2X63QS6 |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family G member 2
(Homo sapiens (Human)) | BDBM50411961
![PNG](/data/jpeg/tenK5041/BindingDB_50411961.png) (CHEMBL261618)Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1ccc(CCN2CCc3ccccc3C2)cc1 Show InChI InChI=1S/C24H23N3O3/c28-24(20-7-11-23(12-8-20)27(29)30)25-22-9-5-18(6-10-22)13-15-26-16-14-19-3-1-2-4-21(19)17-26/h1-12H,13-17H2,(H,25,28) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay |
Bioorg Med Chem 16: 8224-36 (2008)
Article DOI: 10.1016/j.bmc.2008.07.034 BindingDB Entry DOI: 10.7270/Q2765GK5 |
More data for this Ligand-Target Pair | |
P-glycoprotein 1
(Homo sapiens (Human)) | BDBM50411961
![PNG](/data/jpeg/tenK5041/BindingDB_50411961.png) (CHEMBL261618)Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1ccc(CCN2CCc3ccccc3C2)cc1 Show InChI InChI=1S/C24H23N3O3/c28-24(20-7-11-23(12-8-20)27(29)30)25-22-9-5-18(6-10-22)13-15-26-16-14-19-3-1-2-4-21(19)17-26/h1-12H,13-17H2,(H,25,28) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description Inhibition of human Pgp in A2780 cells after 30 mins by calcein AM assay |
Bioorg Med Chem 16: 2448-62 (2008)
Article DOI: 10.1016/j.bmc.2007.11.057 BindingDB Entry DOI: 10.7270/Q2QN67PT |
More data for this Ligand-Target Pair | |