BDBM50413089 CHEMBL487782

SMILES: COc1ccc(OCCN(CC(=O)NCC(C)C)Cc2ccc(F)cc2)cc1OC

InChI Key: InChIKey=QWSXRCNRONNHQX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50413089   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50413089 (CHEMBL487782) Show SMILES COc1ccc(OCCN(CC(=O)NCC(C)C)Cc2ccc(F)cc2)cc1OC Show InChI InChI=1S/C23H31FN2O4/c1-17(2)14-25-23(27)16-26(15-18-5-7-19(24)8-6-18)11-12-30-20-9-10-21(28-3)22(13-20)29-4/h5-10,13,17H,11-12,14-16H2,1-4H3,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	562	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacopeia, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human OX2 receptor expressed in HEK293 cells assessed as inhibition of human orexin-A-stimulated calcium release by FLIPR assa...				Bioorg Med Chem Lett 18: 5420-3 (2008) Article DOI: 10.1016/j.bmcl.2008.09.038 BindingDB Entry DOI: 10.7270/Q27082N5
					More data for this Ligand-Target Pair