BindingDB PrimarySearch

BDBM50414921 CHEMBL570812

SMILES: COc1nn(-c2ccc(NC(=O)OCc3ccccc3)c(C)c2)c(=O)o1

InChI Key: InChIKey=QTENHWTVRQKWRI-UHFFFAOYSA-N

Data: 24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50414921
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
University of Pisa Curated by ChEMBL					Assay Description Inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate after 30 mins				Bioorg Med Chem 22: 3285-91 (2014) Article DOI: 10.1016/j.bmc.2014.04.057 BindingDB Entry DOI: 10.7270/Q2P84DGB
University of Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of rat FAAH				J Med Chem 63: 5783-5796 (2020)
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
University of Pisa Curated by ChEMBL					Assay Description Irreversible inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate preincubated for 30 mins followed by substrate addition				Bioorg Med Chem 22: 3285-91 (2014) Article DOI: 10.1016/j.bmc.2014.04.057 BindingDB Entry DOI: 10.7270/Q2P84DGB
University of Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
University of Pisa Curated by ChEMBL					Assay Description Irreversible inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate preincubated for 60 mins followed by substrate addition				Bioorg Med Chem 22: 3285-91 (2014) Article DOI: 10.1016/j.bmc.2014.04.057 BindingDB Entry DOI: 10.7270/Q2P84DGB
University of Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Jamia Hamdard (Hamdard University) Curated by ChEMBL					Assay Description Inhibition of human MAGL using 4-Nitrophenylacetate substrate incubated for 15 mins				Bioorg Med Chem Lett 24: 3986-96 (2014) Article DOI: 10.1016/j.bmcl.2014.06.029 BindingDB Entry DOI: 10.7270/Q2XP76J6
Jamia Hamdard (Hamdard University) Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Ferrara Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate after 30 mins by fluorescence assay				Eur J Med Chem 97: 289-305 (2015) Article DOI: 10.1016/j.ejmech.2015.04.064 BindingDB Entry DOI: 10.7270/Q29S1SR3
Universit£ di Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Ferrara Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 0 min followed by substrate addition by ...				Eur J Med Chem 97: 289-305 (2015) Article DOI: 10.1016/j.ejmech.2015.04.064 BindingDB Entry DOI: 10.7270/Q29S1SR3
Universit£ di Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Ferrara Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 30 mins followed by substrate addition b...				Eur J Med Chem 97: 289-305 (2015) Article DOI: 10.1016/j.ejmech.2015.04.064 BindingDB Entry DOI: 10.7270/Q29S1SR3
Universit£ di Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Ferrara Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 60 mins followed by substrate addition b...				Eur J Med Chem 97: 289-305 (2015) Article DOI: 10.1016/j.ejmech.2015.04.064 BindingDB Entry DOI: 10.7270/Q29S1SR3
Universit£ di Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic ac...				Eur J Med Chem 63: 64-75 (2013) Article DOI: 10.1016/j.ejmech.2013.01.050 BindingDB Entry DOI: 10.7270/Q2377B2N
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for...				Eur J Med Chem 63: 64-75 (2013) Article DOI: 10.1016/j.ejmech.2013.01.050 BindingDB Entry DOI: 10.7270/Q2377B2N
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of FAAH (unknown origin)				Eur J Med Chem 63: 64-75 (2013) Article DOI: 10.1016/j.ejmech.2013.01.050 BindingDB Entry DOI: 10.7270/Q2377B2N
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of MAGL (unknown origin) using 4-nitrophenylacetate as substrate				Eur J Med Chem 63: 64-75 (2013) Article DOI: 10.1016/j.ejmech.2013.01.050 BindingDB Entry DOI: 10.7270/Q2377B2N
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of MAGL (unknown origin)				Eur J Med Chem 63: 64-75 (2013) Article DOI: 10.1016/j.ejmech.2013.01.050 BindingDB Entry DOI: 10.7270/Q2377B2N
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	20.4	n/a	n/a	n/a	n/a	n/a	n/a
Universite Catholique de Louvain Curated by ChEMBL					Assay Description Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation counting				J Med Chem 52: 7310-4 (2009) Article DOI: 10.1021/jm901323s BindingDB Entry DOI: 10.7270/Q2319X48
Universite Catholique de Louvain Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	77.6	n/a	n/a	n/a	n/a	n/a	n/a
Universite Catholique de Louvain Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH-maltose binding protein				J Med Chem 52: 7310-4 (2009) Article DOI: 10.1021/jm901323s BindingDB Entry DOI: 10.7270/Q2319X48
Universite Catholique de Louvain Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of recombinant human MAGL using 1,3-dihydroxypropan-2-yl 4-pyren-1-yl-butanoate as substrate after 45 mins by fluorescence-based reversed ...				Bioorg Med Chem 25: 825-837 (2017) Article DOI: 10.1016/j.bmc.2016.11.025 BindingDB Entry DOI: 10.7270/Q20C4XQH
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemical and Pharmaceutical Sciences, University of Ferrara , 44121 Ferrara, Italy. Curated by ChEMBL					Assay Description Inhibition of recombinant human MAGL using 4-NPA as substrate after 10 mins in presence of DTT by colorimetric analysis				J Med Chem 61: 1340-1354 (2018) Article DOI: 10.1021/acs.jmedchem.7b01845 BindingDB Entry DOI: 10.7270/Q2JM2D3V
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of recombinant human MAGL				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
Universit£ de Lille Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of rat FAAH				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
Universit£ de Lille Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of Pisa Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His-tagged MAGL expressed in Escherichia coli using 4-NPA as substrate measured after 30 mins				Eur J Med Chem 157: 817-836 (2018) Article DOI: 10.1016/j.ejmech.2018.08.038 BindingDB Entry DOI: 10.7270/Q2MS3WG9
University of Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
University of Pisa Curated by ChEMBL					Assay Description Inhibition of human recombinant MAGL using 4-NPA as substrate after 30 mins				J Med Chem 62: 1932-1958 (2019) Article DOI: 10.1021/acs.jmedchem.8b01483
University of Pisa Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human recombinant MAGL				J Med Chem 63: 5783-5796 (2020)
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50414921 (CHEMBL570812) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
University of Pisa Curated by ChEMBL					Assay Description Irreversible inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate				Bioorg Med Chem 22: 3285-91 (2014) Article DOI: 10.1016/j.bmc.2014.04.057 BindingDB Entry DOI: 10.7270/Q2P84DGB
University of Pisa Curated by ChEMBL					More data for this Ligand-Target Pair